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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, given that they also have problems with weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie diet and exercise, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% as opposed to participants who were given placebos) during a 12- month period, while a different study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to lose weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err assisting caution and allow FDA do its job and demand some research be done so your public recognizes the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on his or her medications.

    Researchers discovered that participants taking this drug for the year, dropped a few pounds within a month and have kept the extra weight off during the entire 56 weeks in the study. Contrave is really a combination of the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them far better and safer.

    Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that by right now there aren't any long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug can also raise blood pressure levels and heartrate, and shouldn't be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.